Table 2.
Treatment | Dose (mg/kg) | Period (week) | ||||||
---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | 5 | 6 | ||
Normal control | — | 32.00 ± 0.88 | 34.00 ± 1.57 | 36.33 ± 0.80 | 38.00 ± 0.82 | 38.50 ± 1.50 | 40.00 ± 0.93 | 40.77 ± 0.99 |
| ||||||||
Diabetic control | — | 35.67 ± 1.52 | 33.50 ± 0.81 | 31.17 ± 0.60α | 30.17 ± 0.89λ | 29.67 ± 0.92λ | 28.17 ± 0.79λ | 27.00 ± 0.52λ |
| ||||||||
Pregabalin | 30 | 33.50 ± 1.92 | 31.17 ± 1.28 | 30.50 ± 1.29β | 29.50 ± 1.15λ | 28.41 ± 1.43λ | 27.83 ± 1.20λ | 26.09 ± 0.73λ |
| ||||||||
Aqueous extract | 150 | 34.12 ± 1.69 | 33.50 ± 0.96 | 31.17 ± 0.46α | 32.00 ± 0.37λ | 34.22 ± 0.28 | 34.50 ± 0.22βc | 35.00 ± 0.58λc |
300 | 34.51 ± 2.03 | 33.67 ± 0.81 | 31.83 ± 0.52 | 32.17 ± 0.48λ | 34.33 ± 0.25 | 36.00 ± 0.32c | 36.67 ± 0.42βc | |
| ||||||||
Methanol extract | 150 | 35.18 ± 1.37 | 34.17 ± 1.49 | 30.67 ± 0.60β | 31.67 ± 0.42λ | 33.00 ± 0.68α | 33.67 ± 0.68λb | 34.08 ± 0.58λc |
300 | 32.33 ± 2.17 | 30.19 ± 1.85 | 29.40 ± 1.74λ | 29.18 ± 1.50λ | 30.67 ± 1.43λ | 31.33 ± 1.33λ | 32.39 ± 1.15λc |
All values are expressed as the mean ± SEM of six animals per experimental group, compared by one-way analysis of variance followed by Tukey test; αp <0.05, βp <0.01, λp <0.001 mean significantly different from the normal control group (nondiabetic); and bp <0.01, cp <0.001 mean significantly different from the diabetic control group.