Table I.

TNFSF ligands present in bony-jawed vertebrates

	TNFSF
	Teleost	Coelacanth	South American Lungfish	African Lungfish	Amphibian	Reptiles	Bird	Mouse	Human
TNFSF1 (LTA)	−	+	+	+	+	+	−	+	+
TNFSF2 (TNF)	+	+	+	+	+	+	+	+	+
TNFSF3 (LTB)	−	+	+	+	+	−	−	+	+
TNFSF4	−	−	−	−	−	+	+	+	+
TNFSF5 (CD40LG)	+	+	+	+	+	+	+	+	+
TNFSF6 (FASLG)	+	+	+	+	+	+	+	+	+
TNFSF7 (CD70)	−	−	−	−	−	−	−	+	+
TNFSF8	−	+	−	+	−	+	+	+	+
TNFSF9	−	−	+	+a	−	+	−	+	+
TNFSF10	+	+	+	+	+	+	+	+	+
TNFSF11	+	+	−	+	+	+	+	+	+
TNFSF12	+	+	−	+	+	+	−	+	+
TNFSF13	+	+	+	+	+	+	−	+	+
TNFSF13B	+	+	+	+	+	+	+	+	+
TNFSF14	+	+	+	+	+	+	+	+	+
TNFSF15	+	+	−	−	−	+	+	+	+
TNFSF18	+	−	−	−	−	+	+	+	+
EDA-A1/EDA-A2	+	+	−	+	+	+	+	+	+
BALM	+	−	−	+	−	−	−	−	−
Ita/TNFN	+	−	−	−	−	−	−	−	−
Total number	14	14	10	15	12	16	12	18	18

Presence and absence of TNF ligands in all vertebrate classes. Only hits with an E-value lower than 1 × 10⁻⁵ were considered. Note that “presence” does not imply orthology with mammalian counterparts.

^aLigands that were not found through BLAST searches but were found using HMM searches. Only hits with an E-value lower than 1 × 10⁻⁵ were considered.