. Author manuscript; available in PMC: 2021 Feb 9.

Published in final edited form as: J Immunol. 2020 Apr 1;204(10):2697–2711. doi: 10.4049/jimmunol.1901059

Table II.

TNFRSF members present in bony-jawed vertebrates

	TNFRSF
	Teleost	Coelacanth	South American Lungfish	African Lungfish	Amphibian	Reptile	Bird	Mouse	Human
TNFRSF1A	+	+	+	+	+	+	+	+	+
TNFRSF1B	+	+	+	+^a	−	+	+	+	+
TNFRSF3 (LTBR)	+	+	+	+	+	−	−	+	+
TNFRSF4	+	+	+^a	−	+	+	+	+	+
TNFRSF5 (CD40)	+	+	+	+	+	+	+	+	+
TNFRSF6 (FAS)	+	+	+	+	+	+	+	+	+
TNFRSF6B	+	+	−	−	+	+	+	+	+
TNFRSF7 (CD27)	+	+	−	+	−	−	+	+	+
TNFRSF8	+	−	+^a	+^a	+	+	+	+	+
TNFRSF9	+	+	+	+	+	+	+	+	+
TNFRSF10A	+	+	+	+	+	+	+	+	+
TNFRSF10B	+	+	+	−	+	+	+	+	+
TNFRSF10C	−	−	+	−	−	−	+	+	+
TNFRSF10D	−	−	−	−	−	−	−	−	+
TNFRSF11A	+	+	+	+	+	+	+	+	+
TNFRSF11B	+	+	+	+	+	+	+	+	+
TNFRSF12A	+	−	−	+^a	+	+	+	+	+
TNFRSF13B	+	+	+	+	−	+	+	+	+
TNFRSF13C	−	−	+^a	−	−	+	+	+	+
TNFRSF14	+	+	+	+	+	+	+	+	+
TNFRSF16 (NGFR)	+	+	−	+	+	+	+	+	+
TNFRSF17	+	+	+	+	+	+	+	+	+
TNFRSF18	+	+	−	−	−	+	+	+	+
TNFRSF19	+	+	−	−	+	+	+	+	+
TNFRSF19L (RELT)	+	+	−	−	+	−	+	+	+
TNFRSF21	+	+	+	+	+	+	+	+	+
EDAR	+	+	−	+^a	+	+	+	+	+
TNFRSF25	+	+	−	−	−	+	+	+	+
TNFRSF27 (EDA2R)	−	+	−	−	+	+	+	+	+
Total number	25	24	18	18	21	24	27	28	29

Presence or absence of TNFRSF molecules in different vertebrate groups. BLAST and reverse-BLAST searches were performed using available transcriptomes and genomes from the main vertebrate groups. Only hits with an E-value lower than 1 × 10⁻⁵ were considered. Note that presence does not imply orthology with mammalian counterparts. TNFR superfamily members present in bony-jawed vertebrates.

Sequences only found through HMM and not found through blasting the created transcriptomes.