Table 4.
Changes of laboratory data for the nine non-survivors
| Baseline | Day 2–4 | Day 5–8 | p value* | |
|---|---|---|---|---|
| WBC (109/L)a | 7.81 ± 2.26 | 13.19 ± 5.54 | 13.63 ± 5.83 | 0.03 |
| Neu (109/L)b | 6.27 ± 1.89 | 11.86 ± 5.45 | 12.61 ± 5.93 | 0.02 |
| Lym (109/L)c | 0.85 ± 0.55 | 0.72 ± 0.28 | 0.49 ± 0.07 | 0.14 |
| BUN (mmol/L)d | 7.70 (5.05, 21.20) | 10.30 (5.40, 20.95) | 11.40 (6.50, 24.00) | 0.71 |
| Creatinine (µmol/L)d | 110.0 (59.5, 188.0) | 84.0 (58.0, 136.0) | 78.0 (60.5, 129.5) | 0.90 |
| d-dimer (µg/mL FEU)d | 2.16 (1.52, 9.69) | 4.64 (2.82, 14.89) | 5.17 (2.28, 10.33) | 0.46 |
| NT-proBNP (pg/mL)d | 943.0 (262.5, 2539.0) | 739.0(385.0, 1985.0) | 1639.0 (546.5, 3098.0) | 0.45 |
| TnI (pg/mL)d | 24.6 (13.9, 65.0) | 17.4 (7.5, 67.4) | 79.8 (19.7, 158.1) | 0.36 |
| CRP (mg/L)d | 119.7(75.5, 144.5) | 133.2 (54.1, 176.6) | 66.9 (53.7, 144.9) | 0.73 |
| Interleukin-6 (pg/mL)d | 60.0 (14.0, 79.2) | 16.4 (11.6, 73.4) | 53.9 (28.6, 84.1) | 0.26e |
WBC white blood cell counts, Neu neutrophil counts, Lym lymphocyte counts, BUN blood urea nitrogen, Cr creatinine, NT-proBNP N-terminal pro-B-type natriuretic peptide, TnI troponin I, CRP c-reactive protein
*p values for the comparison of biomarkers at baseline, day 2–4 and day 5–8. One-way ANOVA or Kruskal–Wallis test according to the characteristics of distribution
ap value (LSD test): baseline vs. day 2–4: 0.03, baseline vs. day 5–8: 0.02, day 2–4 vs. day 5–8: 0.85
bp value (LSD test): baseline vs. day 2–4: 0.02, baseline vs. day 5–8: 0.01, day 2–4 vs. day 5–8: 0.74
cp value (LSD test): baseline vs. day 2–4: 0.46, baseline vs. day 5–8: 0.05, day 2–4 vs. day 5–8: 0.21
dMedian (interquartile range)
eEight patients