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. 2021 Jan 27;11:606689. doi: 10.3389/fphar.2020.606689

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Copyright © 2021 Li, Cao, Lu, Li, Pang, Fu, Fang, Chen, Liu, Wu, Zhou and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Change in metabolic profiles of IgAN rats upon ZWT treatment. (A) PCA plots [positive (A) and negative (B) ion mode] displaying grouped discrimination among the three groups, based on the first two principal components. (B) Loading plots of PLS-DA model [positive (A) and negative (B) ion mode] derived from the potential biomarker metabolites in the serum samples of normal, model, and ZWT groups. (C) Top 10 important discriminatory metabolites upon ZWT treatment, as identified using KEGG pathway enrichment analysis. (D) Schematic overview of bile secretion metabolic pathway changes in IgAN rats upon ZWT treatment. The metabolites are shown in color: red color represents an increase in the levels of metabolite, while green color represents a decrease.