Table 1.

Basic data and descriptive statistics of the primary (TCGA) and secondary (TMA) dataset of HNSCC patients

	Primary dataset (TCGA)			Secondary dataset (TMA)
	Total (n = 510)	Percent (%)	chi2 p value	Total (n = 102)	Percent (%)
Sex
Female	132	26		23	23
Male	378	74	0.480	79	77
Age
< 60	231	45		41	40
≥ 60	279	55	0.344	61	60
Primary
Oral cavity	307	60		20	20
Oropharynx	79	15		53	52
Hypopharynx	10	2		18	18
Larynx	114	22	< 0.001	11	11
HPV
Negative	413	81		74	7
positive	76	15	0.019	25	25
x	21	4		3	3
T stage
1	34	7		21	21
2	148	29		52	51
3	133	26		19	19
4	180	35	< 0.001	10	10
x	15	3		0	0
N stage
0	237	46		7	7
1	81	16		29	28
2	162	32		63	62
3	9	2	< 0.001	3	3
x	21	4		0	0
M stage
0	480	94		70	69
1	6	1	0.350	0	0
x	24	5		32	31
Staging
I	20	4		1	1
II	94	18		3	3
III	103	20		27	26
IV	280	55	< 0.001	71	70
x	13	3		0	0
Smoker
Never/ex	323	63		40	39
Active	173	34	< 0.001	62	61
x	14	3		0	0
Radiotherapy
No	86	17		0	0
Adjuvant	189	37		102	100
Primary	18	4		0	0
Neoadjuvant	6	1	< 0.001	0	0
x	211	41		0	0
Pharmaceutical therapy
No	129	25		85	83
Adjuvant	113	22		16	16
Primary	4	1		0	0
Neoadjuvant	8	2	< 0.001	0	0
x	256	50		0	0

p value below 0.05 was considered significant and highlighted (bold)

Statistical correlations to the TMA dataset were analyzed using Chi-squared test. A