Table 2.

Uni- and multivariable analysis of overall survival for mRNA expression, CNV and protein expression of YY1, CP2 and the YY1CP2 score

	Univariable			Multivariable
	HR	95% CI	p value	HR	95% CI	p value
mRNA expression (n = 510)
YY1 high vs. low	1.35	1.03–1.78	0.030	1.26	0.94–1.68	0.127
YY1 z score	1.08	0.99–1.19	0.068	1.05	0.94–1.18	0.365
CP2 high vs. low	1.11	0.84–1.45	0.465	1.24	0.94–1.65	0.133
CP2 z score	1.07	0.95–1.20	0.262	1.14	1.00–1.29	0.049
YY1CP2 score	1.55	1.16–2.05	0.003	1.60	1.19–2.16	0.002
mRNA expression—interaction analysis (n = 510)
YY1 + (ref. YY1 − CP2 −)	0.97	0.66–1.43	0.892	0.89	0.59–1.34	0.570
CP2 + (ref. YY1 − CP2 −)	0.74	0.48–1.13	0.165	0.82	0.52–1.29	0.398
YY1 + CP2 +	1.96	1.12–3.43	0.018	1.99	1.11–3.58	0.021
CNV (n = 510)
YY1 high vs. low	1.33	1.02–1.75	0.036	1.19	0.89–1.59	0.230
YY1 values	1.20	0.63–2.31	0.582	1.10	0.57–2.12	0.778
CP2 high vs. low	0.83	0.63–1.09	0.185	0.90	0.68–1.20	0.479
CP2 values	0.88	0.30–2.58	0.813	1.16	0.37–3.58	0.803
YY1CP2 score	1.10	0.81–1.49	0.555	1.07	0.78–1.48	0.669
Protein expression (n = 102)
YY1	0.66	0.31–1.40	0.281	0.63	0.28–1.44	0.275
CP2	0.90	0.52–1.57	0.712	1.05	0.59–1.88	0.861
YY1CP2 score	0.60	0.27–1.33	0.207	0.66	0.29–1.51	0.320

p value below 0.05 was considered significant and highlighted (bold)

mRNA levels were analyzed for their expression level (high vs. low) and per change of z score unit. Multivariable analysis was adjusted for staging, HPV status and smoker status. For mRNA expression, the pair-wise interaction for high expressions of YY1 and CP2 was calculated. A p value below 0.05 was considered significant and highlighted (bold).

HR, hazard ratio, CI confidence interval, ref. reference, + high expression, − low expression