Table 1.
Baseline Clinicopathological Data of Patients with HNSCC and Expression of p53 and TLR9 in Relation to HPV and p16 Status
| HPV | p16 | ||||||
|---|---|---|---|---|---|---|---|
| Clinicopathological Variables | n | Positive (n=24) | Negative (n=61) | P value | High (n=27) | Low (n=58) | P value |
| Age | |||||||
| <60 | 40 (47.06%) | 16 | 24 | 19 | 21 | ||
| >60 | 45 (52.94%) | 8 | 37 | 0.023 | 8 | 37 | 0.003 |
| Sex | |||||||
| Male | 69 (81.18%) | 19 | 50 | 22 | 47 | ||
| Female | 16 (18.82%) | 5 | 11 | 0.766 | 5 | 11 | 0.961 |
| Smoking history | |||||||
| >10 pack-year | 58 (68.24%) | 12 | 46 | 14 | 44 | ||
| <10 pack-year | 27 (31.76%) | 12 | 15 | 0.024 | 13 | 14 | 0.027 |
| Alcohol intake | |||||||
| >3U/d | 48 (56.47%) | 10 | 38 | 11 | 37 | ||
| <3U/d | 37 (43.53%) | 14 | 23 | 0.084 | 16 | 21 | 0.046 |
| T class | |||||||
| T1-T2 | 41 (48.24%) | 13 | 28 | 15 | 26 | ||
| T3-T4 | 44 (51.76%) | 11 | 33 | 0.492 | 12 | 32 | 0.356 |
| N class | |||||||
| N0-N1 | 33 (38.82%) | 5 | 28 | 6 | 27 | ||
| N2-N3 | 52 (61.18%) | 19 | 33 | 0.033 | 21 | 31 | 0.032 |
| Stage | |||||||
| I–II | 20 (23.53%) | 4 | 16 | 5 | 15 | ||
| III–IV | 65 (76.47%) | 20 | 45 | 0.349 | 22 | 43 | 0.457 |
| Tumor site | |||||||
| Oropharynx | 35 (41.18%) | 18 | 17 | 20 | 15 | ||
| Larynx | 30 (35.29%) | 3 | 27 | 4 | 26 | ||
| Hypopharynx | 14 (16.47%) | 2 | 12 | 2 | 12 | ||
| Oral cavity | 6 (7.06%) | 1 | 5 | 0.001 | 1 | 5 | 0.001 |
| Differentiation | |||||||
| Well | 18 (21.18%) | 2 | 16 | 2 | 16 | ||
| Moderate | 33 (38.82%) | 6 | 27 | 8 | 25 | ||
| Poor | 34 (40.00%) | 16 | 18 | 0.006 | 17 | 17 | 0.008 |
| Treatment | |||||||
| Sx±(C)RT | 51 (60%) | 13 | 38 | 14 | 37 | ||
| (C)RT±Sx | 34 (40%) | 11 | 23 | 0.491 | 13 | 21 | 0.295 |
| p53 | |||||||
| High | 52 (61.18%) | 3 | 49 | 5 | 47 | ||
| Low | 33 (38.82%) | 21 | 12 | 0.00 | 22 | 11 | 0.00 |
| TLR 9 | |||||||
| High | 42 (49.41%) | 7 | 35 | 8 | 34 | ||
| Low | 43 (50.59%) | 17 | 26 | 0.019 | 19 | 24 | 0.013 |
Note: Significant results (P < 0.05) are given in bold.