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. 2021 Feb 9;12:877. doi: 10.1038/s41467-021-20893-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Expression of human mesothelin (hMeso) in engineered ID8.hMeso cells as detected by flow cytometry. Representative histogram (gray–isotype, blue—hMeso) is shown. hMeso-specific mouse CAR-T cells labeled with cell trace violet (a fluorescent dye that is diluted with cell proliferation) were cocultured with ID8 or ID8.hMeso target cells in the presence of flow-sorted FRβ⁻ or FRβ⁺ TAMs for 72 h. b Representative histograms looking at cell trace violet staining on CAR⁺ T cells (gated on live, CD3⁺GFP⁺, left panel) as well as mean percentage of divided cells ± SD of triplicates (right panel) are shown. c mIFN-γ levels in 72 h supernatants as detected by ELISA. Mean of technical duplicates ± SD is shown. b, c Representative data from two independent experiments. P values by a one-way ANOVA with Tukey’s multiple comparison test are indicated. Source data are provided in the Source Data file.