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. 2020 Oct 26;476(2):699–713. doi: 10.1007/s11010-020-03937-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Silencing MSC-AS1 suppressed the growth of TMZ-resistant glioma cells in vivo. LN229/TR or SHG-44/TR cells transfected with sh-NC or sh-MSC-AS1 were inoculated into the flanks of nude mice. a and b Tumor volume and weight were measured in nude mice inoculated with LN229/TR cells. c The levels of MSC-AS1, miR-373-3p, and CPEB4 were detected by qRT-PCR in resected tumor tissues. d CPEB4 protein expression in resected tumor tissues was determined by western blot. e and f Tumor volume and weight were examined in nude mice inoculated with SHG-44/TR cells. g The levels of MSC-AS1, miR-373-3p, and CPEB4 in tumor tissues of nude mice inoculated with SHG-44/TR cells were analyzed by qRT-PCR. h The protein expression of CPEB4 was measured by western blot. i The protein levels of MCL-1, MRP-1, cyclinD1, Bax, P-PI3K, P-AKT, and caspase-3 in resected tumor tissues of nude mice inoculated with LN229/TR or SHG-44/TR cells were detected by western blot. *P < 0.05