Table 2.
The baseline characteristics of the study subjects by serum alanine aminotransferase and gamma-glutamyltransferase grading in longitudinal analysis.
| Characteristics | ALT grading, IU/L | ||||
|---|---|---|---|---|---|
| Q1 (3–16) | Q2 (17–21) | Q3 (22–31) | Q4 (32–198) | P for trend | |
| n = 1724 | n = 1400 | n = 1719 | n = 1547 | ||
| Age (years) | 52.19 ± 7.58 | 54.90 ± 8.96 | 56.03 ± 9.04 | 54.92 ± 8.18 | < 0.001 |
| Men, no. (%) | 348 (20.2) | 563 (40.2) | 1115 (64.9) | 1288 (83.3) | < 0.001 |
| BMI (kg/m2) | 21.52 ± 2.46 | 22.30 ± 2.69 | 23.01 ± 2.62 | 24.37 ± 2.70 | < 0.001 |
| SBP (mm Hg) | 108.9 ± 13.74 | 113.61 ± 14.92 | 117.54 ± 16.06 | 120.90 ± 15.29 | < 0.001 |
| DBP (mm Hg) | 68.61 ± 9.49 | 70.96 ± 9.99 | 73.09 ± 10.52 | 75.03 ± 10.61 | < 0.001 |
| FBG (mg/dL) | 89.95 ± 5.59 | 90.77 ± 5.32 | 91.25 ± 5.54 | 91.94 ± 5.14 | < 0.001 |
| Total cholesterol (mg/dL) | 171.03 ± 30.40 | 179.39 ± 30.21 | 186.00 ± 31.73 | 193.47 ± 33.91 | < 0.001 |
| HDL-C (mg/dL) | 55.67 ± 12.45 | 54.37 ± 12.56 | 51.83 ± 12.81 | 48.38 ± 11.38 | < 0.001 |
| TG (mg/dL) | 84.61 ± 41.70 | 99.77 ± 63.10 | 121.08 ± 73.01 | 157.90 ± 104.22 | < 0.001 |
| LDL-C (mg/dL) | 100.36 ± 27.76 | 106.42 ± 27.74 | 111.25 ± 29.09 | 115.10 ± 31.97 | < 0.001 |
| Alcohol (g/wk) | 17.07 ± 52.40 | 31.11 ± 77.88 | 47.31 ± 90.14 | 67.70 ± 119.01 | < 0.001 |
| Uric acid (mg/dL) | 4.19 ± 1.07 | 4.59 ± 1.20 | 5.17 ± 1.30 | 5.86 ± 1.38 | < 0.001 |
| Current smoker, no. (%) | 224 (13.0) | 328 (23.4) | 627 (36.5) | 716 (46.3) | < 0.001 |
| HTN, no. (%) | 39 (2.3) | 52 (3.8) | 95 (5.7) | 115 (7.7) | < 0.001 |
| Hyperlipidemia, no. (%) | 19 (1.1) | 38 (2.8) | 74 (4.4) | 94 (6.3) | < 0.001 |
| Internal years | 9.86 ± 3.48 | 9.34 ± 3.51 | 9.35 ± 3.53 | 9.42 ± 3.54 | |
| GGT grading, IU/L | |||||
|---|---|---|---|---|---|
| Q1 (4–12) | Q2 (13–17) | Q3 (18–29) | Q4 (30–198) | P for trend | |
| n = 1581 | n = 1497 | n = 1736 | n = 1576 | ||
| Age (years) | 52.32 ± 7.86 | 54.69 ± 2.27 | 55.26 ± 8.65 | 55.58 ± 8.07 | < 0.001 |
| Men, no. (%) | 134 (8.5) | 518 (34.6) | 1252 (72.1) | 1410 (89.5) | < 0.001 |
| BMI (kg/m2) | 21.66 ± 2.42 | 22.20 ± 2.64 | 23.06 ± 2.80 | 24.25 ± 2.69 | < 0.001 |
| SBP (mm Hg) | 109.13 ± 14.41 | 112.64 ± 15.01 | 116.59 ± 14.99 | 122.10 ± 15.31 | < 0.001 |
| DBP (mm Hg) | 68.83 ± 9.41 | 70.56 ± 9.90 | 71.87 ± 10.28 | 76.22 ± 10.68 | < 0.001 |
| FBG (mg/dL) | 89.79 ± 5.62 | 90.57 ± 5.43 | 91.31 ± 5.46 | 92.13 ± 5.04 | < 0.001 |
| Total cholesterol (mg/dL) | 169.97 ± 28.84 | 178.89 ± 31.65 | 185.19 ± 31.52 | 194.81 ± 33.51 | < 0.001 |
| HDL-C (mg/dL) | 56.85 ± 12.27 | 54.83 ± 12.81 | 50.40 ± 12.13 | 48.65 ± 11.63 | < 0.001 |
| TG (mg/dL) | 78.96 ± 36.65 | 93.94 ± 48.03 | 121.84 ± 71.99 | 165.58 ± 106.76 | < 0.001 |
| LDL-C (mg/dL) | 98.91 ± 25.48 | 107.36 ± 28.92 | 111.50 ± 29.30 | 114.72 ± 32.17 | < 0.001 |
| Alcohol (g/wk) | 7.19 ± 30.75 | 18.35 ± 51.64 | 43.51 ± 93.78 | 91.80 ± 123.37 | < 0.001 |
| Uric acid (mg/dL) | 3.94 ± 0.92 | 4.53 ± 1.15 | 5.27 ± 1.23 | 5.98 ± 1.31 | < 0.001 |
| Current smoker, no. (%) | 75 (4.7) | 259 (17.3) | 713 (41.1) | 848 (53.8) | < 0.001 |
| HTN, no. (%) | 39 (2.5) | 51 (3.5) | 95 (5.6) | 116 (7.6) | < 0.001 |
| Hyperlipidemia, no. (%) | 14 (0.9) | 37 (2.6) | 74 (4.4) | 100 (6.6) | < 0.001 |
| Follow-up period (years) | 9.50 ± 3.50 | 9.46 ± 3.49 | 9.54 ± 3.50 | 9.51 ± 3.59 | |
Q1 1st quartile, Q2 2nd quartile, Q3 3rd quartile, Q4 4th quartile, ALT alanine aminotransferase, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FBG fasting blood glucose, HDL-C high-density lipoprotein cholesterol, TG triglycerides, LDL-C lowdensity lipoprotein cholesterol, HTN hypertension, GGT gamma-glutamyltransferase.