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. 2021 Feb 9;11:3426. doi: 10.1038/s41598-021-83022-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CXCR7 is the most abundantly expressed 7TMR in the murine heart. (a) Expression levels of 7TMRs in murine hearts determined by bulk RNA-seq. The 30 most strongly expressed 7TMRs are shown in the order of their mRNA expression levels. Data represent the mean expression levels from two mice. (b) smFISH for Cxcr7 mRNA (red dots). Each dot indicates a Cxcr7 mRNA molecule in a 10-μm-thick frozen heart section. Cell membranes were stained with Wheat Germ Agglutinin and Alexa Fluor 488 Conjugate to delineate cardiomyocytes and other cell types. White arrow, Cxcr7 mRNA molecules in cardiomyocytes; arrowheads, Cxcr7 mRNA molecules in the interstitial area (non-cardiomyocytes). (c) Single-cell RNA-seq profiles of chemokine receptors and CXCL12 expressed on cardiomyocytes (n = 64), endothelial cells (n = 42), fibroblasts (n = 32), macrophages (n = 10), and smooth muscle cells (n = 6) in the wild-type murine heart.