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. 2021 Feb 9;11:3426. doi: 10.1038/s41598-021-83022-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Deletion of Cxcr7 in cardiomyocytes exacerbates post-infarction remodeling. (a) Representative images of infarcted hearts from Ctl and CKO mice 4 weeks after ligation of a left anterior descending artery to induce myocardial infarction. (b) Heart weight-to-tibia length ratio (HW/TBL) of infarcted mice. sham-Ctl, n = 10; sham-CKO, n = 9; MI-Ctl, n = 15; MI-CKO, n = 9. Data are shown as the mean ± SEM. Significance was calculated by one-way ANOVA followed by the Bonferroni procedure. *P < 0.05, ***P < 0.001. (c) Representative B-mode images of transthoracic echocardiography at diastole and systole of sham and infarcted hearts in Ctl and CKO mice. The dashed line indicates the endocardial surface of the left ventricular (LV) cavity. (d) Left ventricular end-diastolic area (LVEDA), end-systolic area (LVESA), and fractional area change (LVFAC) assessed by echocardiography 4 weeks after myocardial infarction. (sham-Ctl, n = 10; sham-CKO, n = 9; MI-Ctl, n = 15; MI-CKO, n = 9). Data are the mean ± SEM. Significance was calculated by one-way ANOVA followed by the Bonferroni procedure. *P < 0.05, **P < 0.01, ***P < 0.001.