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. 2021 Feb 10;6:55. doi: 10.1038/s41392-020-00412-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Distinct mutational statuses of known cancer-related genes. a Mutations in known cancer-related genes in the CGC database that were detected in more than one GB-NEC sample. b Mutations in genes mutated specifically in GB-NECs or GBCs. c Comparison of RB1/NAB2 protein expression between RB1/NAB2 mutant and wild-type samples (t test). d IHC results at different magnifications from RB1 wild-type and mutant samples; IHC results at different magnifications from NAB2 wild-type and mutant samples. Scale bars in the figures with 50×, 100×, and 200× magnification indicate 500, 200, and 100 μm, respectively