Fig. 4.

Clinical relevance of mutated genes in GB-NECs. a Genes with disease-related mutations detected in GB-NECs. b Detailed mutation information on genes with potential clinically actionable mutations recorded in the OncoKB database. c Detailed mutation sites of ALK. d Genes mutated specifically in stage N0 and N1/N2 GB-NECs. e Survival analysis of patients with CTNNB1 mutations compared with those without CTNNB1 mutations. f Detailed mutation sites of CTNNB1. g IHC results of β-catenin in the four GB-NEC samples with CTNNB1 mutations. Scale bars in the figures indicate 100 μm