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. 2020 Nov 20;26(2):e279–e289. doi: 10.1002/onco.13573

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© 2020 The Authors. The Oncologist published by Wiley Periodicals LLC on behalf of AlphaMed Press.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Concordance and alteration analysis with diagnostic accuracy of eight genes. “All Genes” includes 323 genes sequenced in tDNA using the FoundationOne Platform; “Shared Genes” includes 70 common genes sequenced in both tDNA and ctDNA. Genes selected for diagnostic accuracy analysis were the top five altered genes (TP53, CDKN2A, TERT, NOTCH1, BRCA2) and four DNA repair genes (APC, ATM, BRCA1, BRCA2). The Materials and Methods section defines concordance, and supplemental online Figure 2 shows analysis of the top 15 genes. Figure formatting adapted from Chae et al. [10].Abbreviations: ctDNA, circulating tumor DNA; PPV, positive predictive value; n/a, non‐applicable; NPV, negative predictive value; tDNA, tumor tissue DNA.