Table 1.
Different Treg subsets identified in human and/or mouse.
| Cell population | Human | Mouse | Reference |
|---|---|---|---|
| CD4+ CD25+ Foxp3+ | ✓ | ✓ | (5, 6) |
| CD4+ Foxp3low CD45RA+ | ✓ | ✗ | (12) |
| CD4+ Foxp3high CD45RA- | ✓ | ✗ | (12) |
| CD4+ Foxp3- IL10+ (Tr1) | ✓ | ✓ | (37) |
| CD4+ Foxp3- TGFβ+ (Th3) | ✓ | ✓ | (38) |
| CD4+ Foxp3- IL35+ (iTr35) | ✓ | ✓ | (39) |
| CD4+ Foxp3- IL10+ TGFβ+ (Treg of B cells) | ✗ | ✓ | (40) |
| CD8+ Foxp3+ and/or CD28- and/or CD25+ | ✓ | ✗ | (41–43) |
| CD8+ CD45RA+ CCR7+ Foxp3+ | ✓ | ✗ | (44) |
| CD8+ CD45RClow/- | ✓ | ✓ | (45) |
| CD8+ CD122+ | ✗ | ✓ | (46) |
| CD8+ HLA-DR+ | ✓ | ✗ | (47) |
| CD8+ HLA-E+ | ✓ | ✗ | (48) |
| CD8+ Qa-1+ | ✗ | ✓ | (48) |
| γδ T cells | ✓ | ✓ | (49) |
| NKT | ✓ | ✓ | (50) |
Treg cells are categorized based on CD4 or CD8 surface markers expression.