Figure 4.

(A) Histogram showing the number of pathogenic variants in the genes encoding DEPs present in our datasets, associated with a phenotype of hereditary ataxia or hereditary spastic paraplegia. Variants reported as common to more than one neurological phenotype are reported in white. (B) Venn diagram showing a speculative overlap of genes encoding some of the identified DEPs in our dataset and rare and deleterious variants underlying other neurodegenerative disorders obtained by Genesis 2.0. Variants in STUB1 were not obtained by Genesis queries, but are included here because of its pathogenic significance.