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. 2021 Jan 27;11:608410. doi: 10.3389/fphar.2020.608410

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Copyright © 2021 Sobota, Gatta, van Hunnik, van Tuijn, Kuiper, Milnes, Jespersen, Schotten and Verheule.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in electrophysiological parameters during administration of XAF-1407 in conscious animals. Prolongation of RR (A), QTc (B), PQ (C) and QRS (D) intervals was observed in goats with normal atria and electrically remodeled atria (N = 9). Statistical comparisons were made between baseline and the doses of 0.3 and 3.0 mg/kg of XAF-1407. Friedman’s test, *p < 0.05. An example of electrocardiogram demonstrating LA pacing (BCL 300 ms) during baseline and after the administration of 3.0 mg/kg of XAF-1407 illustrate the presence of second degree AV block after the drug administration (E). Prolongation of Wenckebach cycle length was observed after the administration of 3.0 mg/kg of XAF-1407 in normal atria (F) as well as in electrically remodeled atria (G). Log-rank test, *p < 0.05, N = 9.