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. 2021 Jan 27;7:603358. doi: 10.3389/fvets.2020.603358

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Copyright © 2021 Constable, Trefz, Sen, Berchtold, Nouri, Smith and Grünberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiac output in healthy neonatal calves (time = −24 h) and after experimentally induced diarrhea and dehydration (time = 0 h). Calves were then randomly assigned to no treatment (Control; black circles, n = 4) or treatment with an intravenous hypertonic saline-dextran (HSD) solution (2,400 mOsm/L NaCl in 6% dextran-70 at 4 ml/kg BW once over 4 min; cyan triangles, n = 4), an isotonic alkalinizing oral electrolyte solution (55 ml/kg BW every 8 h for three treatments; pink circles, n = 4); or a combination of intravenous HSD and oral treatments (blue triangles, n = 4). *P < 0.05, compared with t = 0 value; ^aP < 0.05 compared with hypertonic saline dextran group; ^bP < 0.05 compared with oral electrolyte solution; and ^cP < 0.05, compared with the untreated control group. Adapted, with permission, from: Constable et al. (66).