Table 4.

Comparison of the Diagnostic Accuracy for Detecting UC and for Severe Endoscopic UC Using Biomarkers

Parameter		WBC (/μL)			NLR			PLR			ESR (mm/hr)			CRP (mg/dL)			FC (µg/g)
		Estimate	Lower	Upper	Estimate	Lower	Upper	Estimate	Lower	Upper	Estimate	Lower	Upper	Estimate	Lower	Upper	Estimate	Lower	Upper
Control vs. UC																	-	-	-
	Cutoff	6,000			2.26			179.8			34			0.2
	Sensitivity	0.729	0.582	0.847	0.542	0.392	0.686	0.354	0.222	0.505	0.617	0.464	0.755	0.574	0.422	0.717
	Specificity	0.740	0.640	0.824	0.906	0.829	0.956	0.906	0.829	0.956	0.865	0.780	0.926	0.833	0.744	0.902
	Positive predictive value	0.583	0.467	0.743	0.743	0.592	0.842	0.654	0.487	0.779	0.690	0.553	0.810	0.628	0.495	0.760
	Negative predictive value	0.845	0.738	0.900	0.798	0.683	0.899	0.737	0.593	0.864	0.822	0.712	0.900	0.800	0.684	0.880
	Positive likelihood ratio	2.800	1.917	4.089	5.778	2.944	11.339	3.778	1.821	7.838	4.556	2.620	7.924	3.447	2.069	5.743
	Negative likelihood ratio	0.366	0.227	0.591	0.506	0.369	0.692	0.713	0.572	0.887	0.443	0.306	0.642	0.511	0.362	0.720
	AUC	0.793	0.713	0.874	0.774	0.690	0.859	0.654	0.556	0.753	0.767	0.677	0.856	0.696	0.596	0.796
Mild to moderate vs. severe
	Cutoff	7,300			3.44			175.9			41			0.8			453
	Sensitivity	0.636	0.308	0.81	0.636	0.308	0.891	0.909	0.587	0.998	0.909	0.587	0.998	0.727	0.390	0.940	0.818	0.482	0.977
	Specificity	0.649	0.475	0.798	0.811	0.648	0.920	0.784	0.618	0.902	0.667	0.490	0.814	0.861	0.705	0.953	0.730	0.559	0.862
	Positive predictive value	0.350	0.209	0.751	0.500	0.301	0.823	0.556	0.358	0.982	0.455	0.286	0.973	0.615	0.381	0.904	0.474	0.297	0.895
	Negative predictive value	0.857	0.604	0.928	0.882	0.656	0.953	0.967	0.805	0.987	0.960	0.773	0.981	0.912	0.713	0.971	0.931	0.736	0.969
	Positive likelihood ratio	1.811	0.969	3.385	3.364	1.507	7.507	4.205	2.214	7.984	2.727	1.657	4.489	5.236	2.150	12.754	3.027	1.664	5.507
	Negative likelihood ratio	0.561	0.248	1.269	0.448	0.202	0.995	0.116	0.018	0.757	0.136	0.021	0.896	0.317	0.120	0.839	0.249	0.070	0.886
	AUC	0.566	0.339	0.794	0.714	0.539	0.888	0.897	0.802	0.992	0.769	0.623	0.915	0.854	0.741	0.966	0.813	0.655	0.972

UC, ulcerative colitis; WBC, white blood cell; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; FC, fecal calprotectin; AUC, area under the curve.