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. 2020 Jun 14;70(3):499–510. doi: 10.1136/gutjnl-2020-321106

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Microbiota composition and diversity in Crohn’s disease (CD), ulcerative colitis (UC) and control subjects. (a) Principal coordinates analysis (PCoA) based on Bray-Curtis distances with proportional normalisation on all operational taxonomic units (OTUs) present in >5% of samples, with samples grouped by disease and activity state. Violin plots show projections of PCoA points into PC1 and PC2. (b) Spearman’s correlations between PC axes and food groups/metadata and alpha diversity. Only categories with significant correlations are represented. The direction and length of the arrows indicate the direction and strength of the correlation. (c) Comparison of Chao1 alpha diversity for disease type and status of patients with IBD vs healthy controls.(d) Comparison of distances between time points from the same subject based on intra-individual Bray-Curtis distances. (e) Comparison of intra-individual and inter-individual Bray-Curtis distances. *p<0.05; **p<0.01; ***p<0.001.