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. 2020 Nov 9;70(3):522–530. doi: 10.1136/gutjnl-2020-322753

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Contribution of phenotypic factors to faecal microbiome changes. Shown are the correlations between different phenotypic factors at SHIP-2 and global changes in the faecal microbiome from SHIP-2 to SHIP-3. Large positive associations indicate greater variation or instability in the faecal microbiome if the respective factor is distinctly elevated (continuous variables) or positive (binary variables). On the other hand, large negative associations suggest stability of the faecal microbiome. *Indicates significant associations (q<0.05). BMI, body mass index; eGFR, estimated glomerular filtration rate; HbA1c, glycated haemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NT-proBNP, N-terminal prohormone of brain natriuretic peptide; SHIP, Study of Health in Pomerania; TSH, thyroid-stimulating hormone.