Table 1.
Demographic data and clinical assessment results in PDM and CON groups.
| PDM (n = 115) | CON (n = 117) | p-value |
|||
|---|---|---|---|---|---|
| Main effect |
Interaction | ||||
| Group | Genotype | ||||
| Age, y/o | 23.5 (2.2) | 24.1 (2.5) | 0.03* | 0.13 | 0.10 |
| Val/Val | 22.8 (1.9) | 24.2 (2.7) | |||
| Val/Met | 24.2 (2.5) | 24.1 (2.6) | |||
| Met/Met | 23.1 (1.7) | 24.0 (2.4) | |||
| Age of menarche, y/o | 12.1 (1.2) | 12.2 (1.2) | 0.44 | 0.88 | 0.82 |
| Val/Val | 12.1 (1.3) | 12.1 (1.3) | |||
| Val/Met | 12.0 (1.2) | 12.3 (1.1) | |||
| Met/Met | 12.2 (1.1) | 12.3 (1.3) | |||
| Gynecological age, years | 11.4 (2.5) | 11.8 (2.7) | 0.12 | 0.18 | 0.08 |
| Val/Val | 10.7 (2.4) | 12.0 (2.7) | |||
| Val/Met | 12.2 (2.9) | 11.8 (2.7) | |||
| Met/Met | 10.9 (1.9) | 11.7 (3.0) | |||
| Menstrual cycle, days | 29.5 (1.5) | 29.7 (1.5) | 0.32 | 0.57 | 0.82 |
| Val/Val | 29.4 (1.6) | 29.5 (1.0) | |||
| Val/Met | 29.5 (1.4) | 29.7 (1.7) | |||
| Met/Met | 29.5 (1.4) | 29.9 (1.5) | |||
| Estradiol (pg/mL) | 139.7 (100.4) | 125.5 (106.7) | 0.33 | 0.07 | 0.70 |
| Val/Val | 106.8 (75.5) | 104.4 (95.7) | |||
| Val/Met | 145.8 (101.9) | 138.2 (117.5) | |||
| Met/Met | 157.4 (111.5) | 125.5 (94.1) | |||
| Age of onset, y/o | 15.1 (2.2) | – | 0.12 | ||
| Val/Val | 15.8 (2.0) | – | |||
| Val/Met | 14.9 (2.2) | – | |||
| Met/Met | 14.8 (2.2) | – | |||
| Pain history, years | 8.3 (3.1) | – | 0.004* | ||
| Val/Val | 7.0 (2.8) | – | |||
| Val/Met | 9.3 (3.5) | – | |||
| Met/Met | 8.2 (2.2) | – | |||
| Pain duration, days | 1.8 (0.8) | – | 0.12 | ||
| Val/Val | 1.8 (0.8) | – | |||
| Val/Met | 1.7 (0.8) | – | |||
| Met/Met | 2.0 (0.8) | – | |||
| Recall numeric pain rating scale | 6.9 (1.5) | – | 0.93 | ||
| Val/Val | 6.8 (1.7) | – | |||
| Val/Met | 6.9 (1.5) | – | |||
| Met/Met | 6.9 (1.3) | – | |||
| MPQ-recalled pain rating scale | 35.4 (13.9) | – | 0.70 | ||
| Val/Val | 33.5 (14.6) | – | |||
| Val/Met | 35.8 (13.9) | – | |||
| Met/Met | 36.2 (13.6) | – | |||
Data are expressed as mean (standard deviation) and *, p < 0.05.
Abbreviations: PDM, primary dysmenorrhea; CON, control; BDNF, brain-derived neurotrophic factor; Val, Valine; Met, Methionine; MPQ, McGill Pain Questionnaire.