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. 2021 Jan 27;9:612669. doi: 10.3389/fbioe.2021.612669

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Copyright © 2021 Santos, Moschetta, Rodrigues, Alpuim and Capasso.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphene substrate increases miniature synaptic activity. (A,B) Representative miniature synaptic currents (mPSCs) are shown in both TCPS and graphene groups; (C) Cumulative probability plots of inter event interval and amplitude of mPSCs were presented in both TCPS and graphene groups. Histogram plots of mPSC frequency (D) and amplitude (C) were to identify the difference of selected index. Note the significant increase in the mPSC frequency (*p < 0.05) and no difference in the mPSC amplitude. Reprinted from Tang et al. (2013) Elsevier ltd.