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. 2021 Jan 27;8:637538. doi: 10.3389/fbioe.2020.637538

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Copyright © 2021 Riching and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signaling pathways that influence direct cardiac reprogramming. Green text/arrows indicate pathways that enhance reprogramming. Red text/arrows indicate pathways that negatively regulate reprogramming. Solid lines indicate direct interactions. Dashed lines indicate indirect or hypothesized interactions. G, H, M, T, GATA4, HAND2, MEF2C, TBX5; RA, Retinoic acid; NICD, Notch intracellular domain. Transcriptionally repressive histone marks: Me3; H3K27me3. Ub; H2AK119 ubiquitination. Transcriptionally activating histone marks: Ac, histone acetylation.