Fig. 4.

Fibrotic scar tissue was inhibited by FE@EVs hydrogel. (A) Images of spinal sections staining laminin and GFAP from SCI and different treatment rats at 56 days postinjury. (B) Quantification of laminin positive area in the lesion site. (C–F) Representative western blotting images and quantification showing NG-2, Neurocan and Laminin protein levels in the lesion region. (G, H) Images and quantification migration of fibroblast treated in different groups; ^&P < 0.05 versus the control group, ^#P < 0.05 versus the control group. (I) Quantification data of fibroblast migrated from the transwell assay of G. N ≥ 4 per group for histology analysis, N ≥ 4 per group for western blot assay.