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. 2021 Jan 27;11:559810. doi: 10.3389/fimmu.2020.559810

Figure 3.

Figure 3

The number of CD4+ but not of CD8+ T cells is reduced in the brain of K14-VEGFR3-Ig mice after TBI. Box plots representing the number and frequency of CD4+ T cells (A, C, respectively) and CD8+ T cells (B, D, respectively), in the brain of WT and TG mice, as analyzed in the perilesional and contralateral cortices (WT ipsi, n = 12; WT contra, n = 7; TG ipsi, n = 10; TG contra, n = 7), or in intact cortices from naïve mice (WT naïve, n = 5, TG naïve, n = 9). A drastic reduction in the number of CD4+ T cells was found in TG mice after injury. A binomial negative regression or a linear mixed model was applied to assess statistical differences in the counts of CD4+ and CD8+ T cells. The Kruskal Wallis test or the paired samples Wilcoxon signed ranked test was used for the analysis of frequency distribution. *p < 0.05; **p < 0.01 and ***p < 0.001 vs. WT ipsi. φp < 0.05; φφp < 0.01 and φφφp < 0.001 vs. TG ipsi. #p < 0.05 vs. WT contra. In all tests, Bonferroni correction was used to adjust p-values in multiple comparisons.