Figure 6.

TBI-induced lesions does not differ between the two genotypes, as inferred by the analysis of MRI at 21 dpi. (A) Representative MR images of WT naïve, WT CCI, TG naïve and TG CCI brains. Perilesional cortices in WT CCI and TG CCI brains are marked with stars. Box plots in (B, C) illustrate the genotype effect on the percentage of contusion volume and of brain atrophy, respectively, over the volume of the hemisphere ipsilateral to the lesion. No significant differences were observed between TG K14-VEGFR3-Ig and WT mice. For the definitions of the contusion volume and of brain atrophy see the main text. (D) When considering the contusion volume and the brain atrophy independently from the genotype, we found a direct correlation between the two parameters. (E) Representative images of WT CCI and TG CCI brains stained for MAP2, NeuN, and GFAP at 30 dpi. No differences in neuronal damage or in neuroinflammation were visible between the two genotypes, supporting the MRI in vivo data. The Kruskal Wallis test was used for the analysis of infarct volume and of tissue loss between the two genotypes. CI: 95% confidence interval. For box plot explanation, refer to the legend of Figure 2 .