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. 2021 Jan 27;10:599204. doi: 10.3389/fonc.2020.599204

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Copyright © 2021 Penet, Kakkad, Wildes and Bhujwalla

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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tCho concentrations in mM derived from the water phase of Panc1, and BxPC3 orthotopic tumor extracts with high-resolution ¹H MRS (tCho=Cho+PC+GPC) compared to normal adjacent pancreas before (A) and after (B) water content correction, (n=3). (C) tCho concentrations in mM averaged for the orthotopic tumors before and after correction as compared to normal pancreas (n=12). Representative ¹H MR spectra of orthotopic Panc1 tumor (D), orthotopic BxPC3 tumor (E) and normal pancreas (F) (x-axis, chemical shift in ppm). Values represent Mean +/- SD. One-way ANOVA P = 0.06 (A) P < 0.004 (B) P < 0.04 (C) Dunnett’s multiple comparison test: *p < 0.05, ***p < 0.005.