TABLE 2.

List of natural compounds, their sources, and pathway modulated in PCa.

Natural compound	Source	Pathway	References
Nobiletin	Citrus peels	TLR4 pathway	(Deveci Ozkan et al., 2020)
Curcumin	Curcumin longa	NF-Kb pathway and AR pathway	(Lajis et al., 2020)
Resveratrol	Grapes and berries	NF-Kb pathway	(Khusbu et al., 2020)
Daucosterol	Crateva adansonii DC	PI3K/Akt pathway	(Zingue et al., 2020)
Silibinin	Silybum marianum	PI3K/Akt pathway, ERK pathway, and JAK/STAT pathway	(Sherman et al., 2020)
Plectranthoic acid	Ficus microcarpa	TGF-β signaling and RAC1 signaling pathway	(Akhtar et al., 2018)
Osthole	Cnidium monnieri	TGF-β signaling and PI3k/AkT/mTOR pathway	(Wen et al., 2015)
Genistein	Soyabeans	TGF-β signaling, Smad4, and p38 MAPK	(Chen et al., 2018)
Oxymatrine	Sophora japonica	TGF-β signaling and Smad signaling	(Liu et al., 2016)
Tannic acid	Oak tree	TGF-β signaling, Smad signaling, SNAIL, and vimentin	(Pattarayan et al., 2018)
Paeoniflorin	Paeonia lactiflora	TGF-β signaling, Smad2/3 signaling inhibition, SNAIL, e-cadherin, and MMP-9 expression	(Wang et al., 2018b)