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. 2021 Jan 19;40:101861. doi: 10.1016/j.redox.2021.101861

Table 1.

Oxidative stress impact on NO bioavailability.

Mechanisms Consequences Impact in PE References
Increased O2•−production Peroxynitrite formation Increased [160,161,162,163]
Sources:NOX2,Xanthine Oxidase, eNOS uncoupling Decreased NO bioavailability
Nitration, inflammation



Increased arginaseactivity l-arginine depletion Increased [[164], [165], [166], [167]]
Increased ADMA levels eNOS uncoupling [168,169]



BH4 oxidation eNOS uncoupling No variation [170]
Decreased NO generation (very few studies)
Increased O2•−production



eNOS S-glutathionylation eNOS uncoupling Increased [171]
Decreased NO generation
Increased O2•−production



LPP-adducts on eNOS eNOS dysfunction
Decreased NO generation Increased [127]

O2•−, superoxide anion; NOX2, NADPH oxidase 2; NO, nitric oxide; ADMA, asymmetric dimethylarginine; BH4, tetrahydrobiopterin; eNOS, endothelial nitric oxide synthase; LPP, lipid peroxidation products.