Table 1.

Clinical details of 40‐year‐old male with GlyR‐antibody PERM

Presentation	Progression	Other clinical aspects	Investigations	Treatment and outcome
Subacute onset of respiratory difficulties, involuntary jerking and dysphagia after a 5‐ day prodromal urinary tract infection	Respiratory difficulties required ventilation. Marked ophthalmoplegia and rigidity with stimulus induced myoclonic jerks to noise and touch	Awake, appropriate behaviour and no cognitive impairment.	CSF: 11 monocytes, OCB negative, normal glucose protein, virology and cultures negative.	Intravenous immunoglobulins, then oral steroids. Required oral and intrathecal baclofen
		Benign anogenital papillomatous lesions	EMG: continuous motor unit activity	At time of first study [5] he was still ventilator dependent. Improvement continued, he suffered one relapse, but eventually good outcome [30].
			Max GlyR‐Ab: Serum: 1:600, CSF: 1:40
			Brain CT scan and MRI normal.

CSF, Cerebral spinal fluid; OCB, Oligoclonal bands, EMG, Electromyography, CT, Computerized tomography scan, MRI, Magnetic resonance imaging. Data are from unpublished information and [5, 30].