T minus 24–48 h	Sleep deprived Nitrous oxide use; approximately 3.3 kg (420 balloons) Cannabis use (4 joints)
T minus 12 h	Onset of chest pain
T 0	Presentation emergency department Electrocardiogram (ECG 1) Coronary angiogram (CAG 1) and (attempt) percutaneous coronary intervention Hs-troponine T 0.418 μg/L Homocysteine 205 μmol/L Vitamin B12 114 pmol/L Folic acid 7.7 nmol/L
T plus 24 h	Hs-troponine T 5.35 μg/L (peak) Transthoracic echocardiogram (TTE 1): reduced left ventricular ejection fraction with apical and mid septal akinesia. No evidence of right–left shunt
T plus 5 days	Homocysteine 86 μmol/L Repeated coronary angiogram (CAG 2) including optical coherence tomography Electrocardiogram (ECG 2) Discharge from hospital
T plus 2 months (outpatient setting)	Repeated transthoracic echocardiogram (TTE 2) showing moderately reduced left ventricular function with anteroseptal wall motion abnormalities No methylenetetrahydrofolate reductase-gene defects