Table 23.

Estimated probability of the MOET at the 99.9th percentile of the exposure distribution in Tier II scenario being below 100 for the non‐Italian populations, impact of dependencies and population differences

Population	Median estimate of the MOET at 99.9th percentile of exposure distribution and 95% CI after adjustment for exposure and toxicology uncertainties quantified for the Italian population	Probability of 99.9%ile MOET < 100, assuming no difference between populations and full independence between exposure and toxicology uncertainties	Estimated shift factor resulting from differences in the effect of uncertainty U20 (processing factors) compared to the Italian population	Probability of 99.9%ile MOET < 100, taking account of dependencies and additional differences in uncertainties compared to the Italian population
Belgian adults	742 [187–2,558]	0.13%	0.33	5–15%
Czech Rep. adults	578 [157–2,374]	0.30%	0.5	1–10%
German adults	670 [192–2,016]	0.10%	0.33	5–15%
Bulgarian children	499 [155–1,344]	0.30%	0.3	10–33%
French children	316 [82–1,608]	4.96%	0.5	10–50%
Dutch children	538 [187–1,273]	0.09%	0.25	10–33%
Danish toddlers	537 [171–1,248]	0.24%	0.25	10–40%
Dutch toddlers	365 [121–965]	1.05%	0.4	10–33%
UK toddlers	472 [153–1,301]	0.31%	0.33	10–33%