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. 2021 Jan 21;11:624529. doi: 10.3389/fphar.2020.624529

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Copyright © 2021 Deng, Yue, Wang, Zhou, Zhou, Liu, Ni, Huang, Qiu, Liu, Tan, Tang, Wang, Ma and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ferroptosis induced by ALI was related to the inhibition of Nrf2-HO-1/GPX4 pathway. (A), (B) The effect of ALI on the protein of Nrf-2, HO-1, and GPX-4 was evaluated by Western blot. (C), (D) Western blot was used to detect the effect of ALI on protein Nrf-2, HO-1, and GPX-4 after Ferrostatin-1 pretreatment. (E), (F) Protein levels of Nrf-2, HO-1, and GPX-4 in HK-2 cells were detected by Western blot after co-treatment of ALI and SNPP. (G), (H) Western blot was used to detect the effects of ALI combined with MT on the protein levels of Nrf-2, HO-1 and GPX-4 in HK-2 cells. ns, no significant; ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001 vs. the control group; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001, ^#### p < 0.0001 vs. the ALI group.