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. 2021 Jan 15;14:626056. doi: 10.3389/fncel.2020.626056

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Copyright © 2021 Van Hook, Monaco, Bierlein and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mEPSC frequency was reduced in D2 mice. (A) Whole-cell voltage-clamp records of mEPSCs recorded in the absence of stimulation for 4 m D2-control (n = 12 cells from five mice) and D2 mice (n = 11 cells from four mice). Single events are the average of events detected in each cell. (B) Mean ± SD of mEPSC frequency was slightly reduced in 4 m D2 mice. Individual points show the average instantaneous frequency for all events from individual cells. The difference was not statistically significant when assessed with a nested t-test. (C) mESPC amplitude was not different between 4 m D2-controls and D2 mice. (D) mEPSCs recorded from TC neurons from 9 m D2-control (n = 15 cells from four mice) and D2 mice (n = 18 cells from six mice). (E) mEPSC frequency was reduced at 9 m. (F) mEPSC amplitude was similar in D2-control and D2 TC neurons at 9 m.