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. 2021 Jan 21;14:616258. doi: 10.3389/fnins.2020.616258

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Copyright © 2021 Jia, Huang, Wang, Zhang, Wang, Zheng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nogo-C regulates cardiomyocyte apoptosis. (A,B) Western blot showing Nogo-C protein expression in rat neonatal Schwann cells transfected with Ad-Nogo-C at 75 MOI or Ad-lacz for 48 h; n = 3 independent experiments. (C,D) TUNEL staining showing apoptotic rates of Schwann cells transfected with Ad-Nogo-C or Ad-lacz; n = 6 independent experiments. Scale bar = 25 μm. **P < 0.001, ***P < 0.001 vs. Ad-lacz cells. (E,F) TUNEL staining showing apoptotic cells in sham and crushed (7 days after the operation) sciatic nerves from WT and Nogo-C^–/– mice. n = 4 mice. Scale bar = 25 μm. (G,H) western blot and average data showing BAX Bcl-2 and MPZ protein levels in sham and crushed sciatic nerves from WT and Nogo-C^–/– mice; n = 3 mice for each group. ^$$$P < 0.001 vs. WT sham, *P < 0.05, ***P < 0.001 vs. Nogo-C^–/– sham, ^###P < 0.001 vs. WT crush.