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. 2021 Jan 21;7:539501. doi: 10.3389/fmed.2020.539501

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Copyright © 2021 Chauvelot, Ferry, Tafani, Diot, Tasse, Conrad, Chidiac, Braun, Lustig, Laurent and Valour.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ability of Corynebacterium spp. isolates to invade osteoblastic cells. (A) Internalization rates of Corynebacterium isolates in MG63 human osteoblasts according to bone and joint infection (BJI) evolution delay, in comparison with S. aureus 6850 (positive control) and S. aureus DU5883 strain, inactivated for the fnbA/B genes (FnBP, negative control). (B) Internalization rates of the Corynebacterium isolates in murine osteoblasts with functional (OB-β1^fl/fl) or deficient (OB-β1^−/−) expression of the integrin β1 subunit, in comparison with S. aureus 6850.