Table 1.
Summary table of the past and current clinical trials on inhaled gases as therapies for PCAS (as of 1st, Dec, 2020).
| Intervention | Study title | Status | Locations | Identifier |
|---|---|---|---|---|
| Nitric oxide | Improving outcomes in cardiac arrest with inhaled nitric oxide | Recruiting | USA | NCT04134078 1 |
| Molecular hydrogen | Efficacy of inhaled hydrogen on neurological outcome following brain ischemia during post-cardiac arrest care: HYBRID II trial (Phase II) | Recruiting | Japan | UMIN000019820 (120) |
| Xenon | Xenon for neuroprotection during post-cardiac arrest syndrome in comatose survivors of an out of hospital cardiac arrest (XePOHCAS) | Recruiting | USA | NCT03176186 2 |
| Molecular hydrogen | The effect and safety of hydrogen inhalation on outcome following brain ischemia during post cardiac arrest care: HYBRID study | Completed | Japan | UMIN000012381 (100) |
| Xenon | Effect of xenon and therapeutic hypothermia, on the brain and on neurological outcome following brain ischemia in cardiac arrest patients (Xe-hypotheca) | Completed | Finland | NCT00879892 (148, 149) |
| Nitric oxide | Inhaled nitric oxide after out-of-hospital cardiac arrest | Terminateda | USA | NCT03079102 |
a
The study has stopped early because of slow enrollment and planned change of institution by a principal investigator and will not start again.