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. 2021 Jan 7;11:611946. doi: 10.3389/fimmu.2020.611946

Figure 2.

Figure 2

Proposed immune response to respiratory syncytial virus (hRSV) or metapneumovirus (hMPV) and non-specific viruses after rBCG-N-hRSV or rBCG-P-hMPV vaccination, respectively. Immunization with rBCG-N-hRSV or rBCG-P-hMPV induces a specific adaptive immune response against hRSV or hMPV, respectively, that will resolve the infection. Trained immunity induction generates a more robust response against other viruses and orchestrates adaptive immune memory against the virus. CD8, CD8+ T cell; CD4, CD4+ T cell; B, B cell; Mo, monocyte; Mφ, macrophage; NK, natural killer.