FIGURE 4.

Candidate transcription factors and RNA-binding proteins participate in the cold response of C. nivalis. (A) Numbers of differentially expressed transcription factors in C. nivalis and C. reinhardtii, classified into transcription factor families. For each family, upregulated and downregulated genes are indicated by the direction of the axis. (B) Graph and table (top) showing protein–protein interaction analysis of DEGs in C. nivalis based on STRING database. DEGs are shown as colored circles and named as nodes (colors are used as a visual aid to identify the nodes), and interactions are shown as lines and named as edges. The graph below represents the interaction between differentially expressed transcription factors and genes related to metabolism in C. nivalis. Avg., average. PPI, protein–protein interaction. (C) Interaction network of differentially expressed clock-relevant genes in C. nivalis. Homologous genes differentially expressed in C. reinhardtii are also shown.