Table 3.
Selected SNPs associated with ITP risk.
| Gene | SNP | Model | Genotype/allele | Control | ITP | OR (95% CI) | Adjusted p value |
||
|---|---|---|---|---|---|---|---|---|---|
| Count | % | Count | % | ||||||
| TIM3 | rs10515746 | Codominant | CC | 291 | 98.6 | 293 | 95.4 | 1.000 | |
| AA | 0 | 0.0 | 0 | 0.0 | _ | _ | |||
| CA | 4 | 1.4 | 14 | 4.6 | 3.572 (1.153–11.064) | 0.027 | |||
| Dominant | CC | 291 | 98.6 | 293 | 95.4 | 1.000 | |||
| CA/AA | 4 | 1.4 | 14 | 4.6 | 3.628 (1.175–11.200) | 0.025 | |||
| Allele | C | 586 | 99.3 | 600 | 97.7 | 1.000 | |||
| A | 4 | 0.7 | 14 | 2.3 | 3.509 (1.140–10.798) | 0.029 | |||
| CD28 | rs1980422 | Codominant | TT | 246 | 83.4 | 233 | 75.9 | 1.000 | |
| CC | 4 | 1.4 | 0 | 0.0 | _ | 0.999 | |||
| CT | 45 | 15.2 | 74 | 24.1 | 1.798 (1.181–2.711) | 0.006 | |||
| Dominant | TT | 246 | 83.4 | 233 | 75.9 | 1.000 | |||
| CC/CT | 49 | 16.6 | 74 | 24.1 | 1.646 (1.095–2.472) | 0.016 | |||
| ICOS | rs6726035 | Recessive | TT | 62 | 21.0 | 89 | 29.0 | 1.000 | |
| CC/CT | 233 | 79.0 | 218 | 71.0 | 1.510 (1.037–2.198) | 0.032 | |||
| Allele | C | 320 | 54.2 | 292 | 47.6 | 1.000 | |||
| T | 270 | 45.8 | 322 | 52.4 | 1.303 (1.037–1.637) | 0.023 | |||
CI, confidence interval; ITP, immune thrombocytopenia; OR, odds ratio; SNP, single-nucleotide polymorphism. Adjusted p value calculated with univariate logistic regression. Bold highlights p < 0.05.