Table 4.
Selected SNPs associated with ITP risk by multivariate logistic regression analysis.
| Gene | SNP | Model | Genotype/allele | Controls | ITP patients | OR (95% CI) | Adjusted p value |
||
|---|---|---|---|---|---|---|---|---|---|
| Count | % | Count | % | ||||||
| TIM3 | rs10515746 | Codominant | CC | 291 | 98.6 | 293 | 95.4 | 1.000 | |
| AA | 0 | 0.0 | 0 | 0.0 | _ | _ | |||
| CA | 4 | 1.4 | 14 | 4.6 | 3.509 (1.128–10.914) | 0.030 | |||
| Dominant | CC | 291 | 98.6 | 293 | 95.4 | 1.000 | |||
| CA/AA | 4 | 1.4 | 14 | 4.6 | 3.617 (1.170–11.185) | 0.026 | |||
| Allele | C | 586 | 99.3 | 600 | 97.7 | 1.000 | |||
| A | 4 | 0.7 | 14 | 2.3 | 3.218 (1.043–9.924) | 0.042 | |||
| CD28 | rs1980422 | Codominant | TT | 246 | 83.4 | 233 | 75.9 | 1.000 | |
| CC | 4 | 1.4 | 0 | 0.0 | _ | 0.999 | |||
| CT | 45 | 15.2 | 74 | 24.1 | 1.788 (1.178–2.713) | 0.006 | |||
| Dominant | TT | 246 | 83.4 | 233 | 75.9 | 1.000 | |||
| CC/CT | 49 | 16.6 | 74 | 24.1 | 1.645 (1.093–2.475) | 0.017 | |||
| ICOS | rs6726035 | Allele | C | 320 | 54.2 | 292 | 47.6 | 1.000 | |
| T | 270 | 45.8 | 322 | 52.4 | 1.276 (1.015–1.605) | 0.037 | |||
CI, confidence interval; ITP, immune thrombocytopenia; OR, odds ratio; SNP, single-nucleotide polymorphism. Adjusted p value calculated with multivariate logistic regression. Bold highlights p < 0.05.