Table 5.
Selected SNPs associated with ITP severity.
| Gene, SNP | Model | Genotype/allele | Non-severe | Severe | OR (95% CI)# | Adjusted p value# | OR (95% CI)* | Adjusted p value* |
||
|---|---|---|---|---|---|---|---|---|---|---|
| Count | % | Count | % | |||||||
| PD1, rs36084323 | Codominant | CC | 48 | 28.2 | 24 | 17.5 | 1.000 | |||
| TT | 28 | 16.5 | 36 | 26.3 | 2.558 (1.274–5.138) |
0.008 | ||||
| CT | 94 | 55.3 | 77 | 56.2 | 1.640 (0.922–2.919) |
0.093 | ||||
| Dominant | CC | 48 | 28.2 | 24 | 17.5 | 1.000 | ||||
| TT/CT | 122 | 71.8 | 113 | 82.5 | 1.851 (1.064–3.221) |
0.029 | ||||
| Recessive | TT | 28 | 16.5 | 36 | 26.3 | 1.000 | ||||
| CC/CT | 142 | 83.5 | 101 | 73.7 | 1.797 (1.029–3.138) |
0.039 | ||||
| Allele | C | 190 | 55.9 | 125 | 45.6 | 1.000 | 1.000 | |||
| T | 150 | 44.1 | 149 | 54.4 | 1.507 (1.093–2.076) |
0.012 | 1.649 (1.186–2.291) |
0.003 | ||
| LAG3, rs870849 | Allele | C | 280 | 82.4 | 243 | 88.7 | 1.000 | 1.000 | ||
| T | 60 | 17.6 | 31 | 11.3 | 0.579 (0.362–0.925) |
0.022 | 0.506 (0.312–0.818) |
0.005 | ||
CI, confidence interval; ITP, immune thrombocytopenia; OR, odds ratio; SNP, single-nucleotide polymorphism. Calculated with #univariate or *multivariate logistic regression under allele model. Bold highlights p < 0.05.