Table 6.
Association between selected SNPs and corticosteroid-sensitivity of ITP patients.
| Gene, SNP | Model | Genotype/allele | Corticosteroid-sensitive | Corticosteroid-resistant | OR (95% CI)# | Adjusted p value# | OR (95% CI)* | Adjusted p value* |
||
|---|---|---|---|---|---|---|---|---|---|---|
| Count | % | Count | % | |||||||
| DNAM1, rs763361 | Codominant | CC | 56 | 52.3 | 54 | 39.4 | 1.000 | |||
| TT | 5 | 4.7 | 18 | 13.1 | 3.719 (1.276–10.838) |
0.016 | ||||
| TC | 46 | 43.0 | 65 | 47.5 | 1.413 (0.825–2.421) |
0.208 | ||||
| Recessive | TT | 5 | 4.7 | 18 | 13.1 | 1.000 | ||||
| CC/TC | 102 | 95.3 | 119 | 86.9 | 3.151 (1.116–8.892) |
0.030 | ||||
| Allele | C | 158 | 73.8 | 173 | 63.1 | 1.000 | 1.000 | |||
| T | 56 | 26.2 | 101 | 36.9 | 1.623 (1.092–2.412) |
0.017 | 1.939 (1.278–2.942) |
0.002 | ||
| ICOS, rs6726035 | Allele | C | 89 | 41.6 | 143 | 52.2 | 1.000 | 1.000 | ||
| T | 125 | 58.4 | 131 | 47.8 | 0.634 (0.439–0.914) |
0.015 | 0.538 (0.366–0.791) |
0.002 | ||
CI, confidence interval; ITP, immune thrombocytopenia; OR, odds ratio; SNP, single-nucleotide polymorphism. Calculated with #univariate or *multivariate logistic regression under allele model.
Bold highlights p < 0.05.