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CIHH rescues epilepsy-induced LTP suppression through the Wnt/β-catenin pathway. (A) Normalized fEPSP amplitudes before and after high-frequency stimulation (HFS). (B) Histograms comparing mean fEPSP amplitudes at 1, 30, and 60 min post-HFS show LTP suppression by epilepsy and rescue by CIHH but not by CIHH + DKK-1. All values are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 by ANOVA. n = 6 rats per group.
