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. 2021 Jan 22;7:579383. doi: 10.3389/fmed.2020.579383

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Copyright © 2021 Bertesi, Fantini, Alecci, Lotti, Martello, Parenti, Carretta, Marconi, Grande, Pincelli and Zanocco-Marani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methylation profile of ZFP36 promoter in dermal fibroblasts from skin biopsies. CpG sites are represented by red vertical bars along the upstream region of ZFP36 transcription start site, which was taken as “+1” position of base counting. The “F1” subregion, between −1,000 and −500, was amplified by PCR after bisulfite conversion and then sequenced to obtain the presented methylation profile. Two fibroblast samples from healthy donors and two lesional fibroblast samples from psoriasis donors were analyzed. White circle, unmethylated CpG; black circle, methylated CpG.