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. 2021 Jan 11;13:611179. doi: 10.3389/fnmol.2020.611179

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Copyright © 2021 Li, Tian, Wu, Xu, Zhang, Sha and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bumetanide (BMT) enhanced spinal mIPSCs and visceral pain threshold in NMD rats. (A) Representative traces of mIPSCs were recorded in spinal dorsal horn neurons of NMD rats before and after incubation of BMT. (B) Bar plots and cumulative probability distributions of the amplitude of mIPSCs recorded in spinal dorsal horn neurons of NMD rats before and after incubation of BMT (**P < 0.01, n = 6 cells for each group, two-sample t-test). (C) Bar plots and cumulative probability distributions of the frequency of mIPSCs recorded in spinal dorsal horn neurons of NMD rats before and after incubation of BMT (P > 0.05, n = 6 cells for each group, two-sample t-test). (D) Behavioral changes of NMD rats after intrathecal injection of BMT at different doses (5, 50, and 500 μM, ***P < 0.001, n = 6 rats for each group, Tukey post hoc test following two-way repeated-measures ANOVA). (E) Behavioral changes of NMD rats after intrathecal injection of BMT (50 μM) for seven consecutive days (**P < 0.01, ***P < 0.001, n = 6 rats for each group, Tukey post hoc test following two-way repeated-measures ANOVA).