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. 2021 Jan 11;13:611179. doi: 10.3389/fnmol.2020.611179

Figure 7.

Figure 7

Interaction of ASIC1 and NKCC1. (A) ASIC1 and NKCC1 were co-located in the spinal dorsal horn neurons. (B) Expression of NKCC1 in the spinal dorsal horn after intrathecal injection of Amiloride in NMD rats (*P < 0.05, n = 6 rats for NMD + DMSO group and n = 5 rats for NMD+Amiloride group, two-sample t-test). (C) Expression of ASIC1 in the spinal dorsal horn after intrathecal injection of BMT in NMD rats (P > 0.05, n = 4 rats for each group, two-sample t-test). (D) Representative traces of sIPSCs recorded in spinal dorsal horn neurons of NMD rats after injection of Amiloride and DMSO. (E) Bar plots and cumulative probability distributions of the amplitude of sIPSCs recorded in spinal dorsal horn neurons of NMD rats after injection of Amiloride and DMSO (*P < 0.05, n = 6 cells for NMD + DMSO group and n = 7 cells for NMD+Amiloride group, two-sample t-test). (F) Bar plots and cumulative probability distributions of the frequency of sIPSCs recorded in spinal dorsal horn neurons of NMD rats after injection of Amiloride and DMSO (*P < 0.05, n = 6 cells for NMD + DMSO group and n = 7 cells for NMD+Amiloride group, two-sample t-test).